Optimisation of a regenerative peripheral nerve interface for sensory feedback

Key Results and Implications

1. Regenerative peripheral nerve interfaces can selectively stimulate single or small groups of axons.
2. Stimulus thresholds required for a regenerative peripheral nerve interface need nanoamp current control.
3. Axon recruitment remains a function of distance which means need to steer the stimulation field or control axon positions.
4. The planar multi-electrode arrays used in this model cannot adequately control the electric field.
5. Living electrodes offer a way forward by seeding neurons into the device to control positioning.